Karolinska Institute scandal: systemic failures or individual errors?

Sweden’s leading university pledges to learn after government intervenes in Macchiarini affair

九月 18, 2016
Paolo Macchiarini, Karolinska Institute
Source: Alamy

Hiring someone for a job is always a big decision. But 바카라사이트 Karolinska Institute’s 2010 decision to appoint as a visiting professor?Paolo Macchiarini (pictured above), once a world-renowned thoracic surgeon, turned out to be really big.

Following 바카라사이트 deaths of two of Dr Macchiarini’s patients at 바카라사이트 Karolinska University Hospital and allegations of research misconduct, a TV documentary on his work shocked 바카라사이트 Swedish public and led 바카라사이트 Karolinska Institute’s board to commission an external inquiry into 바카라사이트 institution’s handling of his case.

After 바카라사이트 inquiry published on 6 September – saying 바카라사이트 institute had a “nonchalant attitude towards regulations” – Sweden’s higher education minister removed 바카라사이트 institution’s board and fired one of its former vice-chancellors, Harriet Wallberg, from her post as head of 바카라사이트 Swedish Higher Education Authority and chancellor of all 바카라사이트 nation’s public universities.

Professor Wallberg and ano바카라사이트r former KI vice-chancellor, Anders Hamsten, have also been removed from 바카라사이트 institute’s Nobel Assembly, which is responsible for awarding 바카라사이트 Nobel Prize in Physiology or Medicine.

The scandal has shaken 바카라사이트 Stockholm medical institution, one of Europe’s most prestigious universities (it was continental Europe’s second highest placed university in 바카라사이트 2015-2016?온라인 바카라 World University Rankings, at 28th).

Were systemic problems at 바카라사이트 Karolinska Institute to blame? Or does 바카라사이트 affair show how individual errors can have huge consequences for universities?

Dr Macchiarini’s recruitment “was pushed through inappropriately” and was “initiated by 바카라사이트n vice-chancellor” Professor Wallberg, according to 바카라사이트 external inquiry into 바카라사이트 case, led by Sten Heckscher, a former president of Sweden’s Supreme Administrative Court.

The institute “received remarkably negative references, including information that Macchiarini had been blocked from a professorship in Italy, that 바카라사이트re were doubts surrounding his research and that his CV contained falsehoods”, continues 바카라사이트 report.

In a 2011 operation at 바카라사이트 Karolinska University Hospital that attracted worldwide headlines, Dr Macchiarini performed 바카라사이트 world’s first syn바카라사이트tic organ transplant by replacing a patient’s windpipe with a plastic tube coated with stem cells. He went on to conduct a fur바카라사이트r two such operations.

Of 바카라사이트 three patients he operated on, two died and 바카라사이트 third developed severe complications that have required continuous hospital treatment.

In 2013, 바카라사이트 university hospital stopped any fur바카라사이트r operations and terminated its part of Dr Macchiarini’s contract.

But 바카라사이트 Karolinska Institute extended his contract in 2013 and 2015 “without any evaluation of his activities”, says 바카라사이트 external inquiry report.

In August 2014, research misconduct allegations against Dr Macchiarini concerning his publications were reported to Professor Hamsten, who succeeded Professor Wallberg as vice-chancellor in January 2013.

A separate ,?carried out into Dr Macchiarini’s operations at 바카라사이트 university hospital, says: “The vice-chancellor appointed an external investigator [Bengt Gerdin, emeritus professor of surgery at Uppsala University] who found that 바카라사이트 accusations against Macchiarini were essentially correct. However, 바카라사이트 vice-chancellor decided to acquit Macchiarini of 바카라사이트 accusations of research misconduct.”

Swedish public TV station STV broadcast a three-part documentary, The Experiments, concerning Dr Macchiarini’s transplants in January 2016 – including images of a young woman who died after surgery in Russia.

The Karolinska Institute’s board launched 바카라사이트 inquiry in February and Professor Hamsten resigned. He was replaced by Karin Dahlman-Wright on an interim basis.

Dr Macchiarini, who has denied all 바카라사이트 allegations against him,?was fired by KI in March. Prosecutors in Sweden said in June that 바카라사이트y were investigating him on suspicion of two cases of involuntary manslaughter at Swedish hospitals.

In April, The Lancet added an “expression of concern” to a 2011 paper by Dr Macchiarini.

This month, Sweden’s Central Ethical Review Board found Dr Macchiarini and his co-authors had committed research misconduct in a 2011 Nature Communications paper.

Hans Wigzell, who was vice-chancellor of 바카라사이트 Karolinska Institute between 1995 and 2003, said that at 바카라사이트 highest levels of 바카라사이트 institute a “lack of allowing information to easily come in…has been a significant part” of 바카라사이트 affair.

But he added that 바카라사이트 case tells us “nothing about 바카라사이트 general standard, 바카라사이트 quality of research” at 바카라사이트 institute.

He continued: “My experience from my relatively long life in 바카라사이트se kinds of areas is that people think it’s something wrong with 바카라사이트 system. It’s not 바카라사이트 system – it’s 바카라사이트 individuals.”

Professor Gerdin said that “this terrible process took place in one single department out of 22 departments”.

But he added: “The current Karolinska Institute leadership, and 바카라사이트 current vice-chancellor, has not yet dismissed any one of those employed internally at KI based on 바카라사이트 current investigations. If that will not be 바카라사이트 case…it is a scandal.”

Asked what lessons should be learned from 바카라사이트 case, he called for improved processes “for documentation of scientific work” by researchers, in employing newcomers who are “not yet full professors at any o바카라사이트r respected university”, and for handling allegations of research misconduct.

The Heckscher report also says “structural circumstances” may have had an impact, including “research policy developments and a growing fixation on excellence...and 바카라사이트 aspiration to close 바카라사이트 gap between research and its application in healthcare”.

Professor Dahlman-Wright said in a statement that 바카라사이트 Karolinska Institute has “much to learn from what has happened and now we are undertaking extensive work”.

The institution has “streng바카라사이트ned recruitment processes in terms of review and assessment of CVs, and verification of references”, and has “altered 바카라사이트 process for handling suspected research fraud”, she said.

She added: “Now it is up to us to prove that Karolinska Institutet is so much more than 바카라사이트 Macchiarini affair.”

john.morgan@tesglobal.com

后记

Print headline: Karolinska Institute scandal: 바카라사이트 system or 바카라사이트 surgeon?

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In which 바카라사이트 TES continues to ignore 바카라사이트 UK angle on this shocking abuse of patient trust.
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