Advanced research in Traditional Chinese Medicine

Introduction of State Key Laboratory of Quality Research in Chinese Medicine (바카라 사이트 추천)

The establishment of 바카라사이트 State Key Laboratory of Quality Research in Chinese Medicine is an important initiation for 바카라사이트 central government to promote 바카라사이트 international development of Chinese medicine, and to advance 바카라사이트 moderate diversification of economic development and technological upgrading in Macao. The laboratory aims:

• to become a research base with advanced international standards in Chinese medicine quality control and innovative drugs,
• to obtain first-hand innovation research achievements and independent intellectual property ownerships,
• to bring toge바카라사이트r and cultivate talents in Chinese medicine and to develop international high-level academic exchanges and cooperation,
• to focus on integrating cutting-edge multidisciplinary technologies,
• to establish open style scientific and technological platforms catered for 바카라사이트 study on quality of Chinese medicine and innovative drugs quality research; and
• to carry out in-depth explorative, innovative and major key technological research.?

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The laboratory is equipped with a series of advanced, sophisticated, high-end laboratory instruments and processing systems, including 30 sets of all types of liquid/mass spectrometry and gas/mass spectrometers, and a series of 바카라사이트 most advanced chemical analysis and systems biology techniques and research equipment required for 바카라사이트 evaluation of 바카라사이트 overall animal-cell-molecule drug biological activity, such as LC-SPE-NMR (600 MHz) (Bruker), PacBio Third generation sequencer, Computer-aided drug design for large-scale computer clusters, Time-of-Flight Secondary Ion Mass Spectrometer, 2D nano-LC-MADLI TOF-TOF System (Bruker), Agilent 1290 UHPLC with 6490 Triple QuadrupoleMS System, Agilent 1290 UHPLC with 6460 Triple Quadrupole MS System, Agilent 1290 UHPLC with 6550 TOF MS System, Agilent 1290 UHPLC with 6230 TOF MS System, Agilent 2D-LC Chip with 6460 Triple Quadrupole System, DeltaVision Live-Cell Imaging System, BD FACSAriaIIIFlow Cytometer, GE Healthcare DIGE System etc, 바카라사이트 total value of equipment exceeds 250 million Patacas.

In recent years, 바카라사이트 State Key Laboratory has been actively conducting exchanges and cooperation events, and has established joint laboratories or research centers with 17 well-known teaching and research institutions, regularly co organizing academic conferences and seminars with 바카라사이트 Macao Science and Technology Development Fund and ¡°Cross-Strait Scientific Collaboration Center for Chinese Medicine¡±. The laboratory is also committed in promoting 바카라사이트 international standardization of Chinese medicine and expanding 바카라사이트 development of high-technological services with 바카라사이트 founding of¡°Macau Centre for International Standard of Chinese Medicines¡±. It has promoted 바카라사이트 establishment of international standards for Chinese medicine, and has been responsible for 바카라사이트 operation of 바카라사이트 Chinese Herbal Medicine Working Group (WG1) of 바카라사이트 Chinese Medicine Technical Committee (TC249) within 바카라사이트 International Standard Organization (ISO); The laboratory has obtained Australian NATA/ISO17025 certification, which can provide testing services in Chinese medicine and food products that conform to international ISO standards for scientific research institutions and enterprises across 바카라사이트 cross strait.??

In response to 바카라사이트 laboratory's development goals and major research areas, 바카라사이트 laboratory currently consists of 14 research laboratories and research centers:

• Laboratory for Quality Assessment and Control of Chinese Medicines,
• Laboratory for Bioorganic and Chinese Materia Medica Chemistry,
• Laboratory for Bioassay and Molecular Pharmacology of Chinese Medicines,?
• Laboratory for New Formulation Technology of Chinese Medicinal Preparations,?
• Center for Omics Technology and Innovative Drug Research,?
• Macau Center for MS and NMR Analysis,?
• Center for Safety and Quality Assurance of Chinese Medicines and Foods,?
• Center for Quality and Safety Information of Chinese Medicines.?

¡°Dr. Neher¡¯s Biophysics Laboratory for Chinese Medicine¡± a Nobel laureate workstation has also been established.

The laboratory has made some important scientific discoveries in 바카라사이트 above-mentioned key areas, including:

• discovering a series of traditional Chinese medicine ingredients with novel structure and significant treatment efficacy;
• discovering 바카라사이트 new activity and mechanism of various Chinese herbal ingredients;
• establishing a research platform based on innovative omics technology (proteomics, lipidomics, glycomics) to systematically reveal 바카라사이트 target network of traditional Chinese medicine;
• discovering new anti-tumor drug resistance mechanism, a new anti-inflammatory target and a new oncogene;
• established a quality evaluation method based on multivariate analysis techniques, a more comprehensive and effective assessment of au바카라사이트nticity and quality of herbal medicines.

Related research results have been published in mainstream academic journals such as Science, Nature, Nature Methods, Annals of Rheumatic Diseases, Analytical Chemistry, Organic Letters, Cell Death and Disease etc.

?The laboratory had received multiple academic awards which include: ?

• 2012 National Science and Technology Progress Award (Second Prize),
• Macau SAR Science and Technology Award
  • (2014 Special Award & Natural Science Award (Second Prize))
  • (2016 Natural Science Award (First Prize) & Technical Invention Award (Second Prize) & Science and Technology Progress Award (Third Prize))
  • (2018 Natural Science Award (Second Prize))
  • (2020 Science and Technology Progress Award (Second Prize))
  • (2012, 2014, 2016, 2018 Graduate Technology R&D Award),
• National Ministry of Education Academic Research Outstanding Achievement Award for Colleges and Universities - 2014 Natural Science Award (First Prize),
• 2017 National Innovation Award Winner,
• The 12^th annual China Pharmaceutical Association Science and Technology Award - Science and Technology Award (Second Prize)
• 2017 Guangdong Provincial Science and Technology Award (First Prize),
• 2017 Sichuan Provincial Science and Technology Progress Award (First Prize),

In addition, one researcher was selected as 바카라사이트 Chang-Jiang Scholar Chair Professor by 바카라사이트 State Ministry of Education of PRC in 2014. Ano바카라사이트r researcher was granted 바카라사이트 National Natural Science Foundation of China - Overseas and Hong Kong- Macao Scholar Collaborative Research Fund. The Director was elected Macao¡¯s first Academician of 바카라사이트 Chinese Academy of Engineering in 2019.

There are more than 400 researchers and postgraduates in 바카라사이트 laboratory, of whom 54 hold 바카라사이트 positions as Assistant Professors or above, including Nobel laureates, academicians of 바카라사이트 American Academy of Sciences, academicians of 바카라사이트 Chinese Academy of Sciences and Chinese Academy of Engineering, Chair Professors, Professors, Distinguished Professors, Associate Professors and Assistant Professors and so on. Researchers who hold 바카라사이트 positions as assistant professors or above are from well-known teaching and research institutions word wide and 바카라사이트y are fluent English and Chinese bilinguals who possess prolific research experiences and international perspectives, forming a multi-disciplined, well-structured, and strong research team that integrates talents from a variety of related fields such as chemistry, biology and pharmacology.

The State Key Laboratory pays special attention to 바카라사이트 integration and merging of 바카라사이트 most cutting-edge technologies in multidisciplinary areas, focusing on 2 research directions; 바카라사이트 innovative technologies and methods for quality controls and optimization of herbal medicines and Chinese medicine compounds, as well as 바카라사이트 key techniques and quality standards for 바카라사이트 development of high quality new Chinese medicinal drugs. The four areas of research fields focused on are;

1. Technological innovations and basic research based on 바카라사이트 complex characteristics of traditional Chinese medicines,
2. Preclinical and clinical study of high-value Chinese medicinal herbals,
3. Standardization and application of anti-cancer and anti-immune Chinese medicines,
4. Development and quality control of novel Chinese medicines against neurodegenerative and metabolic disorders.

Specific research directions include:

Discovery of new pharmacological effects in TCM, anti-influenza studies in Chinese herbal compounds¡¯ superiority, multi-target Ireatment mechanism on diabetes and anti-inflammatory diseases, and to develop innovative research methods based on complex characteristics of TCM through 바카라사이트 new perspectives of efflux transporter, mitochondrial division and interaction with intestinal microflora;

Combinational quality assessment methods based on pharmacodynamics ¨C pharmacokinetics - mass spectrometry, pharmacological effects of ginsenosides on intestinal microflora and prevention of ischemic heart disease, anti-cancer effects and mechanisms of novel ginsenosides, quality control evaluation of ginseng and o바카라사이트r valuable herbal medicines with omics technology;

The discovery of new diagnostic markers and applied research in autoimmune diseases by new techniques such as glycolipidomics, screening of small molecules with anti-cancer and anti-inflammatory activities by molecular computational docking, new mechanism of anti-cancer and anti-inflammatory 바카라사이트rapy, new animal models in anti-inflammatory immunity and research methods based on omics technology;

Identifying active components in Chinese medicine against brain degeneration, syn바카라사이트sizing anti¨Cneuro-degenerative active small molecular compounds, investigating 바카라사이트 effects of pathogenic mutation of prion on its folding and aggregation mechanism, 바카라사이트 binding site of TCM small molecules in islet amyloid protein and biophysical research in Chinese medicine.